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Funding for new Research Training Group RTG 2467 „Intrinsically Disordered Proteins – Molecular Principles, Cellular Functions, and Diseases“ granted by the DFG

Approximately 40% of amino acid sequences in higher eukaryotes are predicted to be intrinsically disordered (intrinsically disordered proteins, IDPs and intrinsically disordered regions,  IDRs) lacking defined structural elements. Many of these flexible  proteins and protein regions remain understudied. This  is despite their importance in regulating fundamental biological  processes and in the generation of dynamic architectural  superstructures, including, e.g., membrane-less organelles.

IDPs/IDRs will be investigated by an interdisciplinary group of research  scientists composed of biochemists, biophysicists, and cell biologists. Their complementary scientific backgrounds will enable studies ranging  from the in vitro characterization of IDPs/IDRs to their  investigation within cells. A major focus will be the study of IDP/IDR  interactions with proteins as well as RNA. All of the planned RTG  projects address key questions on the molecular processes that  govern how a single IDP/IDR might adopt multiple conformations upon  protein- or RNA-binding.

New publication!

New publication!

Have a look here https://doi.org/10.1016/j.ijbiomac.2021.04.032 …
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New publication!

New publication!

Have a look here https://www.biorxiv.org/content/10.1101/2020.09.25.312835v1.full.pdf …
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New publication!

New publication!

Exploring Phosphoinositide Binding Using Native Mass SpectrometryHave a look here https://link.springer.com/protocol/10.1007/978-1-0716-1142-5_11 …
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New publication!

New publication!

Identification and initial characterization of POLIII-driven transcripts by msRNA-sequencing Please take a look here https://doi.org/10.1080/15476286.2020.1871216 …
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New joint paper!

New joint paper!

IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancerhttps://doi.org/10.1080/15476286.2020.1812894  …
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New publication!

New publication!

Structural analysis of 70S ribosomes by cross-linking/mass spectrometry reveals conformational plasticityPlease take a look here https://doi.org/10.1038/s41598-020-69313-3   …
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