Unveiling Druggable Pockets by Site-Specific Protein Modification: Beyond Antibody-Drug Conjugates

Dailén G. Martínez, Stefan Hüttelmaier and Jean B. Bertoldo

Frontiers in Chemistry


Published 21st October 2020

Structural models of human ACE2 variants with SARS-CoV-2 Spike protein for structure-based drug design

Marija Sorokina, João M. C. Teixeira, Susana Barrera-Vilarmau, Reinhard Paschke, Ioannis Papasotiriou, João P. G. L. M. Rodrigues & Panagiotis L. Kastritis 

Scientific Data volume 7, Article number: 309 (2020)


Published 16th September 2020

Alternatively spliced isoforms of AUF1 regulate a miRNA-mRNA interaction differentially through their YGG motif

Lennart Sänger, Julian Bender, Katja Rostowski, Ralph Golbik, Carla Schmidt, Hauke Lilie, Sven-Erik Behrens & Susann Friedrich

RNA Biology 2020


 Published 14 September 2020

IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer

Nadine Bley, Annekatrin Schott, Simon Müller, Danny Misiak, Marcell Lederer, Tommy Fuchs, Chris Aßmann, Markus Glaß, Christian Ihling, Andrea Sinz, Nikolaos Pazaitis, Claudia Wickenhauser, Martina Vetter, Olga Ungurs, Hans-Georg Strauss, Christoph Thomssen and Stefan Hüttelmaier
RNA Biology 2020
Published 02 September 2020

Unstructured regions of large enzymatic complexes control the availability of metabolites with signaling functions

Ioannis Skalidis, Christian Tüting & Panagiotis L. Kastritis

Cell Communication and Signaling volume 18, Article number: 136 (2020)


Published 26th August 2020

Structural analysis of 70S ribosomes by cross-linking/mass spectrometry reveals conformational plasticity

Christian Tüting Claudio IacobucciChristian H IhlingPanagiotis L KastritisAndrea Sinz
Scientific Reports 2020
Published 28 July 2020

Enhanced optical imaging properties of lipid nanocapsules as vehicles for fluorescent conjugated polymers

Paola Modicano, Paul Robert Neumann, Moritz Schüller, Joost Holthof, Fotis L.Kyrilis, Farzad Hamdi, Panagiotis L. Kastritis, Karsten Mäder, Lea Ann Dailey

European Journal of Pharmaceutics and Biopharmaceutics Volume 154, September 2020, Pages 297-308


Published 22nd July 2020

Constructing artificial respiratory chain in polymer compartments: Insights into the interplay between bo3 oxidase and the membrane

Nika Marušič, Lado Otrin,  Ziliang Zhao, Rafael B. Lira,  Fotis L. Kyrilis, Farzad Hamdi, Panagiotis L. Kastritis, Tanja Vidaković-Koch, Ivan Ivanov,  Kai Sundmacher, Rumiana Dimova


Cross-linking/mass spectrometry at the crossroads

Lolita Piersimoni &  Andrea Sinz 
Analytical and Bioanalytical Chemistry (2020)
Published 29 May 2020
Flexibility of intrinsically disordered degrons in AUX/IAA proteins reinforces auxin co-receptor assemblies

Michael Niemeyer, Elena Moreno Castillo, Christian H. Ihling, Claudio Iacobucci, Verona Wilde, Antje Hellmuth, Wolfgang Hoehenwarter, Sophia L. Samodelov, Matias D. Zurbriggen, Panagiotis L. Kastritis, Andrea Sinz & Luz Irina A. Calderón Villalobos

Published 08 May 2020
Evaluation of NHS-Acetate and DEPC labelling for determination of solvent accessible amino acid residues in protein complexes
Marie Barth, Julian Bender, Til Kundlacz, Carla Schmidt
Journal of Proteomics Volume 222, 30 June 2020, 103793
Published 27 April 2020