RTG 2467 students visit the Forschungszentrum Jülich 19.09.-20.09.2023
Our second cohort PhD student Toni Traeger, along with associated post-doc Ioannis Skalidis visited the Ernst-Ruska Center for Electron Microscopy at the Forschungszentrum Juelich.
After a successful application, Toni brought samples of the natively purified Pyruvate Dehydrogenase Complex (PDHc) in order to collect high-resolution cryo-EM data with the TFS Krios G4 located at the Center. He was introduced to the instrument by the members of the Sachse group, which focuses on cryo-EM instrumentation and method development.
Toni was also given a tour of the whole facility, and saw in-person the advanced instrumentation available there. After fruitful discussions on the potential progress of the project, as well as general discussions on microscopy and cryo-EM image analysis, Toni was allowed to “pilot” the advanced EM and under the supervision of the responsible scientist Saba Shahzad screened and collected data on the PDHc sample, which will, without a doubt, help advance not only Toni’s PhD project but also our knowledge on the Pyruvate Dehydrogenase complex, a large enzymatic machinery whose function is governed by disordered regions.
Summer BBQ Halle (Saale) 01.07.2023
Successful PhD defense of Ioannis Skalidis (Summa cum laude!)
Title "On the molecular organization of a succinyl-CoA-producing cell-free system: A cryo-EM and computational approach"
Halle (Saale) 16.06.2023
RTG2467 Students-only retreat
RTG2467 Annual Fall Meeting
Kloster Nimbschen/Grimma 17.11.-19.11.2022
After two years, we finally met in person again at the monastery Nimbschen close to Grimma. We had a very successful scientific meeting! Congratulations to Tala Alakhras and Coninika Guha who received the awards for best talk “Characterization of Cyclin L protein and its oncogenic role mediated by the RS domain” and for best poster presentation “Paraspeckle as a therapeutic target for inhibition of tumor progression and metastasis”.
2nd Fall Meeting of the German Society for Mass Spectrometry (DGMS) Young Scientists
Kloster Hünfeld 28.09.-30.09.2022
The 2nd Fall Meeting of the German Society for Mass Spectrometry (DGMS) Young Scientists was held at the monastery Hünfeld. Alan An Jung Wei held a talk about his work on his PhD project on “Different Oligomeric States of the Tumor Suppressor p53 Show identical Binding Behavior towards the S100ß Homodimer”. Alessio Di Ianni presented his work “A Novel Trifunctional MS-cleavable Cross-linker for Copper-Catalyzed Azide/Alkyne Cycloaddition (CuAAC) Enrichment of Cross-linked Peptides”. Wiebke Günther presented her poster on the “Application of the Protease Nepenthesin for Hydrogen-Deuterium Exchange Mass Spectrometry”. All projects received a lot of attention and we were able to have interesting conversations with other young scientists. Wiebke won a prize for her poster. Besides listening to the talks and discussing our work, we were able to network with other students and industry partners during the evening events.
Prof. Dr. Julia Laskin, Department of Chemistry, Purdue University, USA “Ambient Imaging of Biological Samples Using Nanospray Desorption Electrospray Ionization (nano-DESI) Mass Spectrometry" 12.07.2022
Gordon Research Conference Intrinsically Disordered Proteins
The Functional Role of Disorder in Biological Systems
Les Diablerets, Switzerland 25.06.2022-01.07.2022
The Gordon Research Seminar and Conference on IDPs was held in Les Diablerets in 2022. Nine RTG students discussed and presented their research with IDP experts. Luca Lauth held a talk about his PhD project on “The primary structure of LCDs that encodes subcellular localization signals”. We received a warm welcome to the international IDP community as we sat together with Keith Dunker and Ya-Yue J. Van Dunker for dinner that evening where Keith again expressed his great interest in our ongoing research. Our projects received a lot of attention at the daily poster sessions and Julia Hesselbarth won a prize at the end of the meeting for her poster on “SNARE complex regulation by Complexin-1 – a structural mass spectrometry study”! Besides listening to and discussing ongoing developments in the field, we had the opportunity to mingle with other scientists and industry partners from around the globe. The meeting was set in the beautiful Bernese Alpes, offering the opportunity to hike and take the gondola up the Glacier3000.