Macromolecular Crowding Induces a Binding Competent Transient Structure in Intrinsically Disordered Gab1

Tobias Gruber, Marc Lewitzky, Lisa Machner, Ulrich Weininger, Stephan M.Feller, Jochen Balbach

Journal of Molecular Biology, Volume 434, Issue 5, 15 March 2022, 167407


Available online 17 December 2021

Disorder-to-order transition of Synaptobrevin-2: Tracing the conformational diversity of a synaptic SNARE protein

Julia Hesselbarth, Carla Schmidt

Journal of Structural Biology Volume 214, Issue 1, March 2022, 107824


Available online 10 December 2021

Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction

Christian Tüting, Fotis L. Kyrilis, Johannes Müller, Marija Sorokina, Ioannis Skalidis, Farzad Hamdi, Yashar Sadian & Panagiotis L. Kastritis

Nature Communications 2021 Nov 26;12(1):6933.

doi: 10.1038/s41467-021-27287-4. PMID: 34836937

Cross-Linking Mass Spectrometry for Investigating Protein Conformations and Protein–Protein Interactions─A Method for All Seasons

Lolita Piersimoni, Panagiotis L. Kastritis, Christian Arlt and Andrea Sinz

Chem. Rev. 20228, 7500–7531


Published 19th November 2021

Small but Mighty—The Emerging Role of snoRNAs in Hematological Malignancies

Jaime Calvo Sánchez and Marcel Köhn
Published 26th October 2021

Thin-Layer Chromatography and Coomassie Staining of Phospholipids for Fast and Simple Lipidomics Sample Preparation

Hofmann T, Barth M, Meister A, Kastritis PL, Schmidt C,

Analysis & Sensing 2021, 1, 171.


Published 02 September 2021

En route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes

Lado Otrin, Agata Witkowska, Nika Marušič, Ziliang Zhao, Rafael B. Lira, Fotis L. Kyrilis, Farzad Hamdi, Ivan Ivanov, Reinhard Lipowsky, Panagiotis L. Kastritis, Rumiana Dimova, Kai Sundmacher, Reinhard Jahn & Tanja Vidaković-Koch

Nature Communications. 2021 Aug 17;12(1):4972.

doi: 10.1038/s41467-021-25294-z. PMID: 34404795

Cross-Linking/Mass Spectrometry Combined with Ion Mobility on a timsTOF Pro Instrument for Structural Proteomics

Christian H. Ihling, Lolita Piersimoni, Marc Kipping and Andrea Sinz

Analytical Chemistry. 2021, 93, 33, 11442–11450
Published 10th August 2021

Nanoscale Model System for the Human Myelin Sheath

Hoffmann M, Haselberger D, Hofmann T, Müller L, Janson K, Meister A, Das M, Vargas C, Keller S, Kastritis PL, Schmidt C, Hinderberger D.

Biomacromolecules. 2021 Sep 13;22(9):3901-3912.

doi: 10.1021/acs.biomac.1c00714. Epub 2021 Jul 29. PMID: 34324309

Effects of non-ionic and zwitterionic detergents on soluble proteins during native mass spectrometry experiments

Til Kundlacz, Julian Bender, Carla Schmidt

International Journal of Massspectrometry Volume 468, October 2021, 116652


Published 11th of June 2021

First 3D-Structural Data of Full-length Guanylyl Cyclase 1 in Rod-Outer-Segment Preparations   of Bovine Retina by Cross-linking/Mass Spectrometry

Anne Rehkamp, Dirk Tänzler, Christian Tüting, Panagiotis L. Kastritis, Claudio Iacobucci, Christian H. Ihling, Marc Kipping, Karl-Wilhelm Koch, Andrea Sinz

Journal of Molecular Biology Volume 433, Issue 10, 14 May 2021, 166947


Published 14th May 2021

Oncogenic Potential of the Dual-Function Protein MEX3A

Marcell Lederer , Simon Müller, Markus Glaß , Nadine Bley, Christian Ihling, Andrea Sinz and Stefan Hüttelmaier 

Biology 2021 10(5), 415


Published 07th of May 2021

Detecting Protein Communities in Native Cell Extracts by Machine Learning: A Structural Biologist’s Perspective

Fotis L KyrilisJaydeep BelapurePanagiotis L Kastritis

Frontiers in Molecular Biosciences

Published 15th April 2021

An anti-HER2 nanobody binds to its antigen HER2 via two independent paratopes

Daniele Ubbiali, Marco Orlando, Matic Kovačič, Claudio Iacobucci, Marta S. Semrau, Gregor Bajc, Sara Fortuna, Gregor Ilc, Barbara Medagli, Sandra Oloketuyi, Paola Storici, Andrea Sinz, Rita Grandori, Ariode Marco

International Journal of Biological Macromolecules


Published 14 April 2021

Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts

Published 09th February 2021

Inactivation of Parathyroid Hormone: Perspectives of Drug Discovery to Combating Hyperparathyroidism

Amit Kumar and Jochen Balbach

Current Mol Pharmacology Volume 15, Issue 2, 2022 

DOI: 10.2174/1874467214666210126112839

Published 26th January 2021

Exploring Phosphoinositide Binding Using Native Mass Spectrometry

Julian Bender & Carla Schmidt

Phosphoinositides pp 157-175

DOI: 10.1007/978-1-0716-1142-5_11


Identification and initial characterization of POLIII-driven transcripts by msRNA-sequencing

Peter Zorn , Danny Misiak, Michael Gekle & Marcel Köhn

RNA Biology


Published 18th of January