Marcel Köhn

Marcel Köhn

studied Biochemistry at the MLU in Halle where he also obtained his PhD in 2015. Since 2015, he is the scientific coordinator of the RTG 1591 “Posttranscriptional Control of Gene Expression” and since 2016, he is head of an independent junior research group at the Medical Faculty of the MLU. Currently, he conducts research in the field of non-coding RNAs in cardiovascular and neoplastic diseases.

Project within the RTG

The RNA-binding protein SRSF1 comprises well structured RRM-Motifs for target RNA recognition and the unstructured IDR consisting of RS-repeats. The main research focus is to analyze the impact of the IDR on SRSF1 protein function. These analyses will be performed on the cellular level to investigate the cellular roles of SRSF1’s IDR and complemented by experiments focussing on the molecular aspects of IDR-mediated RNA-protein interactions. These anaylses will help to elucidate the role of intrinsically disordered regions on the functions of RNA-binding proteins like SRSF1.

Key publications

Köhn M, Hüttelmaier S. Non-coding RNAs, the cutting edge of histone messages. RNA Biol. 2016, 13: 367-372.

Köhn M, Ihling CH, Sinz A, Krohn K, Hüttelmaier S. The Y3** ncRNA promotes the 3′ end processing of histone mRNAs. Genes Dev. 2015, 29: 1998-2003.

Köhn M, Pazaitis N, Hüttelmaier S. Why YRNAs? About versatile RNAs and their functions. Biomolecules. 2013, 3: 143-156.