Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1
Lisa Machner, Alaa Shaikhqasem, Tobias Gruber, Farzad Hamdi, Constanze Breithaupt, Judith Kniest, Felix Wiebe, Marc Lewitzky, Christoph Parthier, Fotis L. Kyrilis, Jochen Balbach, Panagiotis L. Kastritis, Stephan M. Feller, Milton T. Stubbs
bioRxiv
Posted December 23rd 2024
The human touch: Utilizing AlphaFold 3 to analyze structures of endogenous metabolons
Träger TK, Tüting C, Kastritis PL
Structure
Published October 3rd 2024
IQD2 recruits KLCR1 to the membrane-microtubule nexus to promote cytoskeletal mechano-responsiveness in leaf epidermis pavement cells
Jonas Buhl, Sandra Klemm, Malte Kölling, Felix Ruhnow, Christian Ihling, Christian Tüting, Pradeep Dahiya, Jacqueline Patzsch, Leia Colin, Gina Stamm, Andrea Sinz, Panagiotos L. Kastritis, Staffan Persson, Katharina Bürstenbinder
bioRxiv
Posted October 1st 2024
Induction of oxidative- and endoplasmic-reticulum-stress dependent apoptosis in pancreatic cancer cell lines by DDOST knockdown
Richard Böhme, Andreas W. Schmidt, Nico Hesselbarth, Guido Posern, Andrea Sinz, Christian Ihling, Patrick Michl, Helmut Laumen, Jonas Rosendahl
Scientific Reports
Published September 2nd 2024
APOBEC3C-mediated NF-κB activation enhances clear cell renal cell carcinoma progression
Nora Hase, Danny Misiak, Helge Taubert, Stefan Hüttelmaier, Michael Gekle, Marcel Köhn
Molecular Oncology
Published August 26th 2024
Disorder-to-order active site capping regulates the rate-limiting step of the inositol pathway
Träger TK, Kyrilis FL, Hamdi F, Tüting C, Alfes M, Hofmann T, Schmidt C, Kastritis PL.
Proc Natl Acad Sci U S A
Published August 20th 2024
Enhancing structural control in covalent organic frameworks through steric interaction-driven linker design
Winter A, Hamdi F, Eichhöfer A, Saalwächter K, Kastritis PL
Chem Sci.
Published August 13th 2024
Structural biology in cellulo: Minding the gap between conceptualization and realization
Kyrilis FL, Low JKK, Mackay JP, Kastritis PL.
Curr Opin Struct Biol.
Published August 2024
Evaluating Imide-Based Mass Spectrometry-Cleavable Cross-Linkers for Structural Proteomics Studies
Alessio Di Ianni, Christian H. Ihling, Tomáš Vranka, Václav Matoušek, Andrea Sinz and Claudio Iacobucci
JACS Au
Published July 16th 2024
A Workflow for Improved Analysis of Cross-Linking Mass Spectrometry Data Integrating Parallel Accumulation-Serial Fragmentation with MeroX and Skyline
Juan Camilo Rojas Echeverri, Frank Hause, Claudio Iacobucci, Christian H Ihling, Dirk Tänzler, Nicholas Shulman, Michael Riffle, Brendan X MacLean, Andrea Sinz
Analytical Chemistry
Published May 14th 2024
Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts
Lisa Schmidt, Christian Tüting, Fotis L. Kyrilis, Farzad Hamdi, Dmitry A. Semchonok, Gerd Hause, Annette Meister, Christian Ihling, Milton T. Stubbs, Andrea Sinz, Panagiotis L. Kastritis
Communications Biology
Published May 10th 2024
Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells
Peter Zorn, Jaime Calvo Sánchez, Tala Alakhras, Barbara Schreier, Michael Gekle, Stefan Hüttelmaier, Marcel Köhn
RAVER1 hinders lethal EMT and modulates miR/RISC activity by the control of alternative splicing
Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex
Fabian Giehler, Michael S. Ostertag, Thomas Sommermann, Daniel Weidl, Kai R. Sterz, Helmut Kutz, Andreas Moosmann, Stephan M. Feller, Arie Geerlof, Brigitte Biesinger, Grzegorz M. Popowicz, Johannes Kirchmair & Arnd Kieser
Nature Communications
Published January 10th 2024
Protein-Rich Rafts in Hybrid Polymer/Lipid Giant Unilamellar Vesicles
Otrin N, Otrin L, Bednarz C, Träger TK, Hamdi F, Kastritis PL, Ivanov I, Sundmacher K.
Effect of Molecular Dynamics and Internal Water Contact on the Photophysical Properties of Red pH-Sensitive Proteins
Schmitt FJ, Mehmood AS, Tüting C, Phan HT, Reisdorf J, Rieder F, Ghane Golmohamadi F, Verma R, Kastritis PL, Laufer J
Biomacromolecules
Published January 2nd 2024