A nested shell structure coordinates enzyme communication in pyruvate oxidation
Toni K. Träger, Sourav Maity, Fotis L. Kyrilis, Christian Tüting, Farzad Hamdi, Greg Kafetzopoulos, Z Faidon Brotzakis, Alexander Neuhaus, Anja Blanque, Christos Gatsogiannis, Georgios Skretas, Wouter H. Roos, Panagiotis L. Kastritis
bioRxiv
Posted May 14th 2026
Native Mass Spectrometry Reveals Binding Modes of the Tumor Suppressor Protein p53 to Different DNA Response Elements
Erik Siefke, Christian Arlt, Andrea Sinz
J. Am. Soc. Mass Spectrom.
Posted May 5th 2026
A 37-million-particle dataset from over 250 experiments to accelerate data-driven cryo-EM analysis
Andreas Zamanos, L. Kyrilis, Panagiotis Koromilas, Panagiotis L. Kastritis, Yannis Panagakis
bioRxiv
Posted May 3th 2026
A Native Nepenthesin Reactor for Improved Proteolytic Digestion of Intrinsically Disordered Proteins in Proteomics Workflows
Christian Wall, Frank Hause, Wiebke Grimm, Florian W. Otto, Erik Siefke, Marc Kipping, Andrea Sinz
ChemBioChem
Posted March 26th 2026
Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1
Lisa Machner, Alaa Shaikhqasem, Tobias Gruber, Farzad Hamdi, Constanze Breithaupt, Judith Kniest, Felix Wiebe, Marc Lewitzky, Christoph Parthier, Fotis L. Kyrilis, Jochen Balbach, Panagiotis L. Kastritis, Stephan M. Feller, Milton T. Stubbs
Structure
Posted March 5th 2026
The intrinsically disordered region of the human parathyroid hormone controls functional amyloid properties
Sachan S, Bhatia T, Baumann M, Weber M, Gordijenko I, Voigt B, Ott M, Balbach J.
J Biol Chem.
Posted February 16th 2026
Accessing new dimensions in high-resolution materials exploration by cryo-electron microscopy
P. Koralli, F.L. Kyrilis, F. Hamdi, C.L. Chochos, P.L. Kastritis
Mater. Sci. Eng. R Rep.
Posted February 6th 2026
Direct evidence of acid-driven protein desolvation
Farzad Hamdi, Ioannis Skalidis, Inken Kaja Schwerin, Jaydeep Belapure, Dmitry A. Semchonok, Fotis L. Kyrilis, Christian Tüting, Johannes Müller, Georg Künze, and Panagiotis L. Kastritis
PNAS
Posted February 4th 2026
Structural basis of Arf1-driven membrane tubulation
Caroline Haupt, Dmitry A. Semchonok, Ambroise Desfosses, Sebastian Daum, Sarah Neudorf, Farzad Hamdi, Panagiotis L. Kastritis, Milton T. Stubbs, Kirsten Bacia
bioRxiv
Posted January 23rd 2026
Revisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels
Vishnupriya Pandey, Frank Hause, Claudio Iacobucci, Christian H. Ihling, Christian Tueting, Panagiotis L. Kastritis, Christian Arlt, Andrea Sinz
bioRxiv
Posted January 20th 2026
Cryo-EM structure of photosystem II supercomplex from a green microalga with extreme phototolerance
Rameez Arshad, Ioannis Skalidis, David Kopečný, Sylva Brabencová, Monika Opatíková, Petr Ilík, Pavel Pospíšil, Farzad Hamdi, Sanja Ćavar Zeljković, Martina Kopečná, Pavel Roudnický, Dušan Lazár, Eduard Elias, Roberta Croce, Panagiotis L. Kastritis & Roman Kouřil
Nat. Commun.
Posted January 9th 2026
Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals
Shaikhqasem A, Hamdi F, Machner L, Parthier C, Breithaupt C, Kyrilis FL, Feller SM, Kastritis PL, Stubbs MT
Acta Crystallogr D Struct Biol.
Posted January 1st 2026